type vii collagen การใช้

• This gene encodes the alpha chain of type VII collagen.
• In the skin, the type VII collagen protein is synthesized by keratinocytes and dermal fibroblasts.
• Type VII collagen is also found in the retina; its function in this organ is unknown.
• Anchoring fibrils composed of type VII collagen extend from the basal lamina into the underlying reticular lamina and loop around collagen bundles.
• The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia.
• Staining with anti-type IV collagen antibodies or anti-type VII collagen antibodies reveals bright, thick bands at the dermoepidermal junction.
• There exist other types of inherited epidermolysis bullosa, junctional epidermolysis bullosa and epidermolysis bullosa simplex, which are not related to type VII collagen deficiency.
• Dystrophic epidermolysis bullosa is caused by genetic defects ( or mutations ) within the human COL7A1 gene encoding the protein type VII collagen ( collagen VII ).
• In the absence of mutations, however, an autoimmune response against type VII collagen can result in an acquired form of this disease called epidermolysis bullosa acquisita.
• The type example for this family is BPTI ( or basic protease inhibitor ), but the family includes numerous other members, such as snake venom basic protease; mammalian inter-alpha-trypsin inhibitors; trypstatin, a rat mast cell inhibitor of trypsin; a domain found in an alternatively spliced form of Alzheimer's amyloid beta-protein; domains at the C-termini of the alpha-3 chains of type VI and type VII collagens; tissue factor pathway inhibitor precursor; and Kunitz STI protease inhibitor contained in legume seeds.